repopulating activity of Overnight transduction with foamyviral vectors restores the long - term
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منابع مشابه
GENE THERAPY Overnight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc / stem cells
Departments of 1Microbiology and Immunology and 2Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis; 3Department of Pediatric Oncology, Hematology and Clinical Immunology, Children’s Hospital, Heinrich Heine University, Duesseldorf, Germany; 4Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany; and 5Center...
متن کاملOvernight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc-/- stem cells.
Fanconi anemia (FA) is a complex genetic disorder characterized by congenital abnormalities, bone marrow failure, and myeloid malignancies. Identification of 13 FA genes has been instrumental to explore gene transfer technologies aimed at correction of autologous FA-deficient stem cells. To date, 3 human FA stem cell gene therapy trials with standard 4-day transduction protocols using gammaretr...
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The use of lentiviral vectors for the transduction of hematopoietic stem cells has evoked much interest owing to their ability to stably integrate into the genome of nondividing cells. However, published large animal studies have reported highly variable gene transfer rates of typically less than 1%. Here we report the use of lentiviral vectors for the transduction of canine CD34(+) hematopoiet...
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There is increasing trend in using recombinant stem cells as novel therapeutic candidates in different diseases. These studies encompass different applications from targeted homing of Mesenchymal Stromal (stem) Cells (MSC), to arming them with different cytokines. Resistance to transfection or transduction methods had urged researchers to look for better gene delivery alternates and optimizing ...
متن کاملEfficient transduction of pigtailed macaque hematopoietic repopulating cells with HIV-based lentiviral vectors.
Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear entry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high titer. Experiments to evaluate HIV-derived lentiviral vectors in nonhuman primates prior to clinical trials have been hampered by low transd...
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تاریخ انتشار 2008